Job Description

Job Details PRIMARY FUNCTION The laboratory of Dr. Mark Tykocinski, former dean of the Sidney Kimmel Medical College of Thomas Jefferson University and recipient of the 2026 FASEB ASIP Gold-Headed Cane Award, is seeking a motivated and talented scientist to join our research team. Our laboratory focuses on the development of novel, dual-targeting fusion protein therapeutics designed to selectively activate or suppress innate and adaptive immune responses. These engineered fusion proteins, targeted to cancer and immune-related diseases, are being advanced via a direct translational pathway into clinical trials, and benefit, in part, from an active partnership with a clinical-stage biotech startup. The successful candidate will leverage training in immunology, structural biology, and molecular biology to design, execute, and analyze experiments that support ongoing and emerging research projects within the lab. Candidates with expertise in immunology and/or protein engineering and prior experience with murine tumor models are strongly preferred. Job Description ESSENTIAL FUNCTIONS * Independently formulate hypotheses and design experiments aligned with lab objectives. * Execute and oversee complex experimental protocols in molecular and cellular biology, protein biochemistry, and immunological assays. * Perform mammalian cell culture using sterile technique, including maintenance and manipulation of immune and tumor cell lines. * Conduct and interpret in vivo experiments using murine models, including tumor engraftment, treatment response monitoring, and tissue collection. * Collect, organize, and analyze experimental data using appropriate statistical and analytical tools. * Present findings in the form of oral presentations and written reports for internal lab meetings, grant submissions, and external conferences. * Draft scientific manuscripts, abstracts, and grant proposals in collaboration with the lab team. * Maintain detailed and accurate electronic records of experimental procedures, data, and protocols. * Stay current with the scientific literature and integrate relevant findings into experimental design. * Collaborate with lab members and external partners to advance project goals and support translational efforts. EDUCATIONAL/TRAINING REQUIREMENTS: Ph.D., in structural biology and molecular biology EXPERIENCE REQUIREMENTS: Previous experience in an academic lab setting preferred. Work Shift Workday Day (United States of America) Worker Sub Type Regular Primary Location Address 1020 Locust Street, Philadelphia, Pennsylvania, United States of America Nationally ranked, Jefferson, which is principally located in the greater Philadelphia region, Lehigh Valley and Northeastern Pennsylvania and southern New Jersey, is reimagining health care and higher education to create unparalleled value. Jefferson is more than 65,000 people strong, dedicated to providing the highest-quality, compassionate clinical care for patients; making our communities healthier and stronger; preparing tomorrow's professional leaders for 21st-century careers; and creating new knowledge through basic/programmatic, clinical and applied research. Thomas Jefferson University, home of Sidney Kimmel Medical College, Jefferson College of Nursing, and the Kanbar College of Design, Engineering and Commerce, dates back to 1824 and today comprises 10 colleges and three schools offering 200 undergraduate and graduate programs to more than 8,300 students. Jefferson Health, nationally ranked as one of the top 15 not-for-profit health care systems in the country and the largest provider in the Philadelphia and Lehigh Valley areas, serves patients through millions of encounters each year at 32 hospitals campuses and more than 700 outpatient and urgent care locations throughout the region. Jefferson Health Plans is a not-for-profit managed health care organization providing a broad range of health coverage options in Pennsylvania and New Jersey for more than 35 years. Jefferson is committed to providing equal educa?tional and employment opportunities for all persons without regard to age, race, color, religion, creed, sexual orientation, gender, gender identity, marital status, pregnancy, national origin, ancestry, citizenship, military status, veteran status, handicap or disability or any other protected group or status. Benefits At Jefferson, we offer a comprehensive total rewards package designed to support the health and well-being of our colleagues and their families. It includes a wide range of benefits including competitive pay, health and retirement benefits, life and disability insurance, paid time off, educational benefits, financial and mental health resources and much more. Our diverse benefits offerings ensure you have the coverage and access to services you need to thrive both personally and professionally.

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